3 edition of NF-[kappa] B found in the catalog.
Includes bibliographical references and index.
|Statement||edited by Louis M. Staudt, Michael Karin.|
|Contributions||Staudt, Louis., Karin, Michael.|
|LC Classifications||QP552.N46 N4 2010|
|The Physical Object|
|LC Control Number||2009048884|
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain. NF-KappaB is found in the cytoplasm sequestered in a complex with I-KappaB (Inhibitor of Kappa Light Chain Gene Enhancer in B-Cells). Phosphorylation of I-KappaB triggers ubiquitin-dependent degradation, and subsequent release of NF-KappaB. NF-KappaB is then free to translocate to the nucleus to activate gene transcription (Ref.5).
Get this from a library! NF-kappa B: methods and protocols. [Michael J May;] -- Annotation This volume guides readers through standard approaches to detect NF-kB pathway activation, detection and analysis of NF-kB signalling, and methods to study the control of NF-kB. Overexpression of TRAF2, but not TRAF1 or TRAF3, was sufficient to induce NF-kappa B activation. A truncated derivative of TRAF2 lacking an amino-terminal RING finger domain was a dominant-negative inhibitor of NF-kappa B activation mediated by TNF-R2 and CD Thus, TRAF2 is a common mediator of TNF-R2 and CD40 signaling.
Central to this equation is a gene signal known as NF-kappaB, which is the basic intelligence within every cell of your body, including the various cells that make up your bones. NF-kappaB is your cellular problem solver, responsible for implementing instructions for your cells to deal with any kind of stress, including type emergencies. A wide range of human disorders involves inappropriate regulation of NF-kappaB, including cancers and numerous inflammatory conditions. Toward our goal to define mechanisms through which NF-kappaB leads to the development of disease, we have developed transgenic mice that express luciferase under the control of NF-kappaB, enabling real-time in vivo imaging of NF-kappaB activity in intact by:
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NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell -κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral : Comprehensive and authoritative, NF-Kappa B: Methods and Protocols provides a timely and invaluable resource for researchers seeking to perform experiments aimed at understanding the role of NF-κB signaling in health and disease.
Nuclear Factor-Kappa B (NF-κB) NF-κB, considered as a central regulator of carcinogenesis, plays a key role in mediating chemoresistance. Several chemotherapeutic agents such as doxorubicin, paclitaxel, vinblastine, daunomycin, 5-FU, cisplatin, and bortezomib have been reported to induce NF-κB activation in different cancer cells [–].
Focusing on essential insight into the methods and techniques required to dissect the complex mechanisms of NF-κB activation, regulation, and function.
NF-kappa B: Methods and Protocols guides NF-[kappa] B book through standard approaches to detect NF-κB pathway activation, detection and analysis of NF. NF-κB is a critical regulator for gene expression induced by diverse stress signals, including mutagenic, oxidative, and hypoxic stresses.
Activation of NF-κB is likely to be involved in the induction of gene expression associated with ischemic adaptation. Studies from our laboratory demonstrated ischemic adaptation translocated and increased the binding activity of NF-κB in heart. NF-kB is a short name of Nuclear Factor kappa-light-chain-enhancer of activated B cells.
It is not a single protein, but a small family of inducible transcription factors that play an important role in almost all mammalian cells. It control DNA transcription, cytokine production, cell survival and other important cell events, especially play a. The nuclear factor-κB (NF-κB) family of transcription factors is activated by canonical and non-canonical signalling pathways, which differ in both signalling components and biological functions.
Recent studies have revealed important roles for the non-canonical NF-κB pathway in regulating different. Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by | Explore the latest full-text research PDFs, articles.
Figure 9. UV crosslinking analysis of proteins binding to HIV and P2 oligonucleotides. (A) Mobility shift analysis of NF-r.B binding activities in PLB (lanes I and 2) and PLBIIIB (lanes 3 and 4) after treatment with TNF for 5 h using BUdR substituted, szP-labeled P2 (lanes 1 and 3) or HIV (lanes 2 and 4) probes.
The nonspecific complex (ns) was not analyzed. (B) The region of the gel. Title:NF-κB as a Target for Modulating Inflammatory Responses VOLUME: 18 ISSUE: 35 Author(s):Chiara Gasparini and Marc Feldmann Affiliation:The Kennedy Institute of Rheumatology, University of Oxford, 65 Aspenlea Road, London W6 8LH, UK.
Keywords:NF-κ B, cytokines, inflammation, anti-inflammatory, small molecules peptides, small molecules nucleic acids, primary. Introduction and background. There is still much that remains unknown within the biology of NF-κB despite the fact that in the year NF-κB celebrated its 25 year anniversary ().NF-κB, also referred to as the Rel family of proteins, was first described in as a protein which binds to specific decameric DNA sequences (ggg ACT TTC C) in mature B-cells nuclear fraction and the.
NF kappa B signaling pathway - This lecture explains about the NF kappa B signaling pathway in details. Every step of NF kappa B signaling is explained along with the role of NF kappa B.
DNase I footprint assays using purified transcription factors revealed the presence of NF-kappa B and AP-2 binding sites in the proximal part of the promoter region of the human HO-1 gene.
Moreover, nucleotide sequence analysis of the HO-1 promoter region showed that the protected regions encompassed NF-kappa B and AP-2 consensus binding sites. Innate Immune Response in Brain, NF-Kappa B Signaling and Cystatins. Overview of attention for article published in Frontiers in Molecular Neuroscience, December Altmetric Badge.
About this Attention Score Above-average Attention Score compared to outputs of the same age (59th percentile). NF-kappaB: a transcription factor that regulates cytokine gene transcription.
NF-κB is a target of glucocorticoid action. Calcineurin stimulates the NF-kappa B element by enhancing inactivation of I kappa B/MAD3, an inhibitor of NF-kappa B, thereby increasing the amount of nuclear NF-kappa B DNA binding activity.
These data provide the first demonstration in vivo that activation of a protein phosphatase can inactivate I kappa B, and suggest one possible. We report a functional consequence of NAC supplementation during doxorubicin (Dox) chemotherapy administration via the NF-kappa B (NF-κB) signal transduction pathway.
The ability of NAC to alter Dox-induced NF-κB activity is contingent on the ROS-mediated S-glutathionylation of IKK-β. Providing contributions from leading authorities involved with seminal discoveries on the subject, Handbook of Transcription Factor NF-kappaB is an entry point to understanding the broad role of this widely studied factor.
Beginning with a summary, the authors introduce the uninitiated reader to the complexities of the NF-kB system. Nuclear factor-kappa B (NF-κB) is a ubiquitously existed transcription factor regulating expression of numerous genes involving in inflammation, immune and cancer progression.
In an inactive status, NF-κB family members exist as dimmers with the predominance of p65/p50 heterodimers and are sequestered in the cytoplasm by members of IκB family. Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways.
Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. Get this from a library! NF-[kappa]B/Rel transcription factor family.
[Hsiou-Chi Liou;] -- Since its first discovery in the early 90's, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries.
NF-kB Transcription Factors. Dr. Thomas D. Gilmore Biology Department, Boston University 5 Cummington Mall, Boston, MassachusettsUSA () or ; fax () The Rel/NF-kappaB Signal Transduction Pathway.().
Different inflammatory mechanisms in lungs of severe and mild asthma: crosstalk of NF‐kappa‐B, TGFβ1, Bax, Bcl‐2, IL‐4 and IgE. Scandinavian Journal of Clinical and Laboratory Investigation: Vol.
69, No. 4, pp.